Modelling and simulation of molecular motor driven cytoskeleton dynamics and its function in the secretory pathway

This Earmarked Scholarship project is aligned with a recently awarded Category 1 research grant. It offers you the opportunity to work with leading researchers and contribute to large projects of national significance.

Supervisor – Dr Dietmar

The project aims to elucidate the impact of cytoskeleton dynamics on morphology and function of neurosecretory cells and of neuron cells using computational simulation and continuum modelling.

It is not well understood how the transport of secretory, respectively synaptic vesicles to their sites of exocytosis is guided and controlled. Since mechanical guidance through the cytoskeleton is believed to play a pivotal role it is our goal to identify the mechanism(s) by which cortical F-actin and microtubules as well as their associated motor proteins contribute to the processes leading to exocytosis, respectively neurotransmitter release. 

Preferred educational background

Applications will be judged on a competitive basis taking into account the applicant's previous academic record, publication record, honours and awards, and employment history.

A working knowledge of (applied) mathematics or (computational) physics would be of benefit to someone working on this project.

A background or knowledge of partial differential equations and some programming language (e.g. Julia, MATLAB, Python, C, or other) is highly desirable.

*The successful candidate must commence by Research Quarter 4, 2022. You should apply at least 3 months prior to the research quarter commencement date. International applicants may need to apply much earlier for visa reasons. 

Apply now