Molecular and cellular determinants of CDCP1 targeted, payload-delivering antibodies

This Earmarked Scholarship project is aligned with a recently awarded Category 1 research grant. It offers you the opportunity to work with leading researchers and contribute to large projects of national significance.

Supervisors – Professor John Hooperjohn.hooper@mater.uq.edu.au and Associate Professor Paul Thomas, paul.thomas@health.qld.gov.au

Preclinical and patient data support the receptor CDCP1 as a rational target for delivery of radionuclides and cytotoxins for detection and treatment of a range of cancers including high-grade-serous ovarian cancer.

The goal of this project is to understand the molecular and cellular determinants that predict the efficacy of CDCP1 targeted biomolecules including antibodies and peptides.

Aims:

  1. To perform mutagenesis studies of the CDCP1 extracellular domain to identify residues required for antibody binding.
  2. To undertake cryo-electron microscopy analysis of antibody/CDCP1 complexes to determine residues and motifs that mediate protein interactions.
  3. To quantify the effect of anti-CDP1 antibody affinity on cellular processing of the receptor.
  4. To determine the impact of affinity on efficacy of anti-CDCP1 antibodies at delivering payloads for detection and treatment of preclinical models of ovarian cancer.

Preferred educational background

Applications will be judged on a competitive basis taking into account the applicant's previous academic record, publication record, honours and awards, and employment history.

A working knowledge of the following topics would be helpful for an incoming student, but not essential:

  • molecular biology
  • structural biology including electronmicroscopy
  • cell biology
  • cancer biology
  • cancer pathology
  • in vitro models of cancer
  • mouse models of cancer
  • immunohistological analysis of tumours

A background or knowledge of in vitro and animal models of cancer is highly desirable.

*The successful candidate must commence by Research Quarter 2, 2022. You should apply at least 3 months prior to the research quarter commencement date. International applicants may need to apply much earlier for visa reasons.

Apply now