Molecular and cellular determinants of CDCP1 targeted, payload-delivering antibodies

This Earmarked Scholarship project is aligned with a recently awarded Category 1 research grant. It offers you the opportunity to work with leading researchers and contribute to large projects of national significance.

Supervisors – Professor John and Associate Professor Paul Thomas,

Preclinical and patient data support the receptor CDCP1 as a rational target for delivery of radionuclides and cytotoxins for detection and treatment of a range of cancers including high-grade-serous ovarian cancer.

The goal of this project is to understand the molecular and cellular determinants that predict the efficacy of CDCP1 targeted biomolecules including antibodies and peptides.


  1. To perform mutagenesis studies of the CDCP1 extracellular domain to identify residues required for antibody binding.
  2. To undertake cryo-electron microscopy analysis of antibody/CDCP1 complexes to determine residues and motifs that mediate protein interactions.
  3. To quantify the effect of anti-CDP1 antibody affinity on cellular processing of the receptor.
  4. To determine the impact of affinity on efficacy of anti-CDCP1 antibodies at delivering payloads for detection and treatment of preclinical models of ovarian cancer.

Preferred educational background

Applications will be judged on a competitive basis taking into account the applicant's previous academic record, publication record, honours and awards, and employment history.

A working knowledge of the following topics would be helpful for an incoming student, but not essential:

  • molecular biology
  • structural biology including electronmicroscopy
  • cell biology
  • cancer biology
  • cancer pathology
  • in vitro models of cancer
  • mouse models of cancer
  • immunohistological analysis of tumours

A background or knowledge of in vitro and animal models of cancer is highly desirable.

*The successful candidate must commence by Research Quarter 2, 2022. You should apply at least 3 months prior to the research quarter commencement date. International applicants may need to apply much earlier for visa reasons.

Apply now