Monitoring inflammation through quantitation of redox-mediated macrophage polarisation

This Earmarked Scholarship project is aligned with a recently awarded Category 1 research grant. It offers you the opportunity to work with leading researchers and contribute to large projects of national significance.

Supervisor – Dr Run

Failure to turn off the body’s immune response results in chronic inflammation characterised by oxidative stress. Such oxidative stress is associated with irreversible cell/tissue damage and linked to a variety of diseases, such as inflammatory arthritis, liver inflammation, and cardiovascular diseases. Therefore, quantitation of these redox biomolecules in macrophages is critical to understand the correlation between redox levels, macrophage polarisation status and inflammation progression.

This project aims to develop and pre-clinically validate advanced responsive probing technology to quantify redox biomolecules produced in macrophages. This research will address major knowledge gaps relating the redox levels with the macrophage polarisation. This information will underpin a novel method for improved diagnosis and monitoring of inflammatory diseases.

The successful student will enrol through the Australian Institute for Bioengineering & Nanotechnology.

Preferred educational background

Applications will be judged on a competitive basis taking into account the applicant's previous academic record, publication record, honours and awards, and employment history.

A working knowledge of chemistry (analytical biochemistry), cell and molecular biology or biomedical engineering would be of benefit to someone working on this project.

*The successful candidate must commence by Research Quarter 4, 2022. You should apply at least 3 months prior to the research quarter commencement date. International applicants may need to apply much earlier for visa reasons.

Apply now