Single molecule sensing on nanopillars: A platform technology for reading complex molecular circuits in a single cell

This Earmarked Scholarship project is aligned with a recently awarded Category 1 research grant. It offers you the opportunity to work with leading researchers and contribute to large projects of national significance.

Supervisor – Professor Matt

Single molecule detection has opened an entirely new direction in life science research. The interaction between biomolecular components within a cell are complex and dynamic, with bulk analytical methods only able to provide averaging information, typically from multi-cellular samples. Single molecule, single cell platforms can overcome this limitation and provide deeper understanding about the dynamic behaviour of individual cells. Moreover, single molecule detection provides the required sensitivity needed to unravel complex and highly dynamic molecular circuits, along with the ability to visualise cellular heterogeneity.

This PhD project aims to develop an entirely new platform technology to visualise these complex and dynamic molecular circuits (e.g. signalling pathways) in real time, and within any biological sample, from single cell extracts to enable a new generation of single molecule sensitive platform.

Preferred educational background

Applications will be judged on a competitive basis taking into account the applicant's previous academic record, publication record, honours and awards, and employment history.

A working knowledge of biotechnology with interest in nanotechnology and microfluidics would be of benefit to someone working on this project.

The applicant will demonstrate academic achievement in the field(s) of nanotechnology and the potential for scholastic success.

A background or knowledge of molecular biology is highly desirable.

*The successful candidate must commence by Research Quarter 1, 2022. You should apply at least 3 months prior to the research quarter commencement date. International applicants may need to apply much earlier for visa reasons.

Apply now